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1 SIFT - Predict effects of nonsynonmous / missense variants
https://sift.bii.a-star.edu.sg/
SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids.
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2 SIFT - bio.tools
https://bio.tools/sift
Sorting Intolerant From Tolerant (SIFT) is a sequence homology-based tool that will predict whether an amino acid substitution will affect protein function.
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3 SIFT -- predicting amino acid changes that affect protein function
https://www.hsls.pitt.edu/obrc/index.php?page=URL1119029663
SIFT (Sorting Intolerant From Tolerant) is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize ...
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4 PROVEAN - J. Craig Venter Institute
https://www.jcvi.org/research/provean
PROVEAN (Protein Variation Effect Analyzer) is a software tool which predicts whether an amino acid substitution or indel has an impact on the biological ...
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5 SIFT - Bioinformatics Home
https://bioinformaticshome.com/tools/descriptions/SIFT.html
SIFT. A web tool to predict the effect of single nucleotide polymorphism (SNP) on protein function. Details; Topic; Publications; Download and documentation ...
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6 Using SIFT and PolyPhen to Predict ... - Mary Ann Liebert, Inc.
https://www.liebertpub.com/doi/10.1089/gtmb.2010.0036
SIFT can choose homologous sequences automatically, or the user can submit selected prealigned sequences to the program. The most accurate ...
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7 SIFT missense predictions for genomes | Nature Protocols
https://www.nature.com/articles/nprot.2015.123
SIFT is an algorithm that predicts whether an amino acid substitution is deleterious to protein function, and it is often used to prioritize ...
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8 SIFT score - Ion Reporter
https://ionreporter.thermofisher.com/ionreporter/help/GUID-2097F236-C8A2-4E67-862D-0FB5875979AC.html
A SIFT score predicts whether an amino acid substitution affects protein function. The SIFT score ranges from 0.0 (deleterious) to 1.0 (tolerated).
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9 Ensembl Variation - Pathogenicity predictions
https://www.ensembl.org/info/genome/variation/prediction/protein_function.html
SIFT predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physico-chemical similarity between the ...
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10 Predicting Amino acid Changes that Affect Protein Function
https://www.researchgate.net/publication/10693514_SIFT_Predicting_Amino_acid_Changes_that_Affect_Protein_Function
Thus, by using sequence homology, SIFT predicts the effects of all possible substitutions at each position in the protein sequence. The protocol ...
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11 SIFT web server: predicting effects of amino acid substitutions ...
https://www.semanticscholar.org/paper/SIFT-web-server%3A-predicting-effects-of-amino-acid-Sim-Kumar/051f851112b1ace45c86a4d37f0478a3e5d2fa6d
SIFT web server: predicting effects of amino acid substitutions on proteins · Ngak-Leng Sim, Prateek Kumar, +3 authors. P. Ng · Published 9 June ...
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12 SIFT :: Genetic Analysis Software | The Rockefeller List
https://gaow.github.io/genetic-analysis-software/s/sift/
SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids.
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13 SIFT.Hsapiens.dbSNP137 - Bioconductor
https://bioconductor.org/packages/release/data/annotation/manuals/SIFT.Hsapiens.dbSNP137/man/SIFT.Hsapiens.dbSNP137.pdf
PROVEAN is a software tool which pre- dicts whether an amino acid substitution or indel has an impact on the biological function of a protein. PROVEAN is useful ...
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14 SIFT & PolyPhen - Functional Prediction of Genetic Variants
https://www.coursera.org/lecture/bioinformatics-pku/conservation-based-and-rule-based-methods-sift-polyphen-jxCxd
Given a protein sequence and an amino acid variation, in Step 1, SIFT searches Swiss-prot database for similar protein sequences using four iterations of PSI- ...
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15 Using computational prediction programs to assist with variant ...
https://www.youtube.com/watch?v=Yb7tBV3AzQ4
National Society of Genetic Counselors
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16 Predicting the effects of coding non-synonymous variants on ...
https://baam.library.gwu.edu/discovery/fulldisplay?docid=cdi_proquest_miscellaneous_67432740&context=PC&vid=01WRLC_GWA:live&lang=en&search_scope=DN_and_CI&adaptor=Primo%20Central&query=creator%2Cexact%2C%20Polak%2C%20Paz%20%2CAND&facet=citing%2Cexact%2Ccdi_FETCH-LOGICAL-c462t-7354efae495eb3e5e13658dc1d1760dda57334e449bf75b5bf7a9b74037ab8da3&offset=40
Thus, by using sequence homology, SIFT predicts the effects of all possible substitutions at each position in the protein sequence. The protocol typically takes ...
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17 Comparative analysis of web-based programs for single ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267084
Sorting Intolerant from Tolerant (SIFT) is a web-server that determines whether single amino acid substitutions on a protein are deleterious or ...
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18 PPVED: A machine learning tool for predicting the effect of ...
https://onlinelibrary.wiley.com/doi/full/10.1111/pbi.13823
Although some software (e.g., SIFT, MAPP, and PROVEAN), developed based on human SAASs, have been applied to predict altered protein ...
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19 Computational and Mass Spectrometry-Based Approach ...
https://www.mdpi.com/1420-3049/26/15/4653/htm
The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine ... At present, we integrated software for predicting damaging nsSNPs SIFT, ...
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20 PolyPhen-2: prediction of functional effects of human nsSNPs
http://genetics.bwh.harvard.edu/pph2/
We aplogize for the inconvenience caused. Query Data. Protein or SNP identifier. Protein sequence in FASTA format.
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21 2D SIFt: a matrix of ligand-receptor interactions
https://jcheminf.biomedcentral.com/articles/10.1186/s13321-021-00545-9
Structural Interaction Fingerprints (SIFts), as described by Deng et al.[1], comprise a method for encrypting protein–ligand interactions in the ...
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22 PASE: a novel method for functional prediction of amino acid ...
https://www.frontiersin.org/articles/10.3389/fgene.2013.00021/full
Widely used software tools are, for example, SIFT (Ng and Henikoff, ... Therefore, any AAS may influence the final protein structure by ...
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23 SIFT - UFRC Help and Documentation
https://help.rc.ufl.edu/doc/SIFT
SIFT predicts whether an amino acid substitution affects protein function. SIFT prediction is based on the degree of conservation of amino ...
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24 Functional Predictions and Conservation Scores in VSClinical
https://blog.goldenhelix.com/clinical-variant-interpretation-part-vi/
For a given protein sequence alignment, SIFT constructs a position-specific scoring matrix (PSSM), which encodes the probability of each ...
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25 Installing SIFT for Missense Variants on Ubuntu
https://bioinformaticsreview.com/20201104/installing-sift-for-missense-variants-on-ubuntu/
SIFT is a bioinformatics tool for predicting missense effects of non-synonymous/missense variations in sequences [1].
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26 Evaluation of computational techniques for predicting non ...
https://www.sciencedirect.com/science/article/pii/S0888754318301800
Mutation Assessor takes protein ID and variants, SIFT takes only variants, ... Models (FATHMM) is software for forecasting the functional impacts of protein ...
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27 LYRUS: A Machine Learning Model for Predicting ... - bioRxiv
https://www.biorxiv.org/content/10.1101/2021.05.10.443497v1.full.pdf
incorporating protein dynamics into pathogenicity predictions. ... We compared our approach to PolyPhen2, PROVEAN, SIFT, Rhapsody, ...
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28 Accelerating genome analysis: Updated software SIFT 4G can ...
https://www.sciencedaily.com/releases/2016/02/160222105517.htm
› releases › 2016/02
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29 Computational Analysis of Single Nucleotide Polymorphism ...
http://article.sapub.org/10.5923.j.ijge.20200801.01.html
It is a software tool which predicts whether an amino acid substitution or indel has an impact on the biological function of a protein. The input was the ...
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30 Using SIFT and PolyPhen to Predict Loss-of ... - Typeset.io
https://typeset.io/papers/using-sift-and-polyphen-to-predict-loss-of-function-and-gain-4y4rzuiy3z
TL;DR: SIFT is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study ...
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31 sift-software [ILRI Research Computing]
https://hpc.ilri.cgiar.org/sift-software
SIFT. SIFT predicts whether an amino acid substitution affects protein function. Information. Version: 4.0.3b.
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32 In silico analysis of non-synonymous single nucleotide ...
https://jmhg.springeropen.com/articles/10.1186/s43042-020-00110-3
SIFT makes a prediction whether substitution of an amino acid has damaging effect on the function of the protein based on sequence alignment ...
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33 ANNOVAR Documentation
http://annovar.openbioinformatics.org/
ANNOVAR is an efficient software tool to utilize update-to-date information to functionally annotate genetic variants detected from diverse genomes ...
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34 DIA-SIFT: A Precursor and Product Ion Filter for Accurate ...
https://pubs.acs.org/doi/10.1021/acs.analchem.8b01618
Figure 3. DIA-SIFT reduces variance to more accurately measure changes in protein levels. (A) Protein quantitative accuracy is improved by DIA- ...
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35 Comprehensive characterization of amino acid positions in ...
https://www.pnas.org/doi/10.1073/pnas.2002660117
Random forest * (P3DFiProtein class, SIFT, PolyPhen2, CADD) ... were calculated using the DSSP (dictionary of protein secondary structure) program (40).
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36 SIFT Program
http://www.protein.osaka-u.ac.jp/biophys/SIFT/index.html
They are available for downloading at http://www.protein.osaka-u.ac.jp/matsuki/SIFT. The SIFT-processed data can be output in nmrPipe format ( ...
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37 Predicting the Most Deleterious Missense Nonsynonymous ...
https://www.hindawi.com/journals/tswj/2021/6642626/
CCBE1 proteins from Hennekam syndrome patients should be tested in animal models for this purpose. ... Sequence Homology Tool (SIFT).
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38 SIFTS (Methodology)< PDBe < EMBL-EBI
https://www.ebi.ac.uk/pdbe/docs/sifts/methodology.html
EMBL EBI PDBe - Protein Data Bank Europe is a European resource for PDB ... protocol and developed software to use sequences of connected segments of a ...
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39 Other prediction tools - Phenosystems
https://www.phenosystems.com/www/index.php/links-to-various-tools-and-information/other-prediction-tools
Align-GVGD is a freely available, web-based program that combines the biophysical characteristics of amino acids and protein multiple sequence alignments to ...
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40 Potential Consequences on Protein Level and using ... - AWS
https://s3-ap-southeast-2.amazonaws.com/ap-southeast-2.accounts.ivvy.com/account613/events/132200/files/5b87431d73f25.pdf
Uses nine established pathogenicity likelihood scores: SIFT, PolyPhen‐2,. CADD, MutationTaster,. MutationAssessor,. FATHMM, LRT, MetaLR, and MetaSVM. 3.
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41 SIFT - biotools - OpenEBench
https://openebench.bsc.es/tool/sift
Description : Sorting Intolerant From Tolerant (SIFT) is a sequence homology-based tool that will predict whether an amino acid substitution will affect ...
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42 Performance of mutation pathogenicity prediction tools on ...
https://www.scielo.br/j/clin/a/8d8Rjfxtxyv7LBHSLTcvbNh/?format=pdf&lang=en
6 (Mutation Assessor, Phanter, SIFT, Mutation Taster, Polyphen-2, and CAAD) exhibited ... based on evolutionary conservation, protein structure/func-.
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43 Alamut™ Visual Plus - Variant Annotation and Analysis Software
https://www.sophiagenetics.com/platform/alamut-visual-plus/
Highly appreciated by its users, the software accelerates the complex and time-consuming assessment of variants thanks to its user-friendly interface and ...
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44 MutationAssessor.org /// functional impact of protein mutations
http://mutationassessor.org/
This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms.
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45 Association between single nucleotide polymorphism of ...
https://www.tandfonline.com/doi/full/10.1080/13102818.2019.1657039
Reportedly, BRCA1 interacting protein C-terminal helicase 1 (BRIP1) gene ... Polyphen and SIFT software were used for prediction of protein functions.
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46 Resource Report - SciCrunch
https://scicrunch.org/resolver/SCR_012813
SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations. (entry from Genetic Analysis Software) Web ...
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47 Mutations or Variations - vls3d.com
https://www.vls3d.com/index.php/links/bioinformatics/mutations
PROVEAN - Protein Variation Effect Analyzer. The performance of PROVEAN is comparable to popular tools such as SIFT or PolyPhen-2 - . SuSPect - ...
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48 Sift Or Polyphen - Biostars
https://www.biostars.org/p/6488/
On the other hand, if you can produce your own alignments then SIFT might be ... SIFT/Polyphen2 is mainly due to evident constraints in protein structure.
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49 SWAAT Bioinformatics Workflow for Protein Structure-Based ...
https://mdpi-res.com/d_attachment/jpm/jpm-12-00263/article_deploy/jpm-12-00263.pdf?version=1644583406
of tools and workflows: SIFT, PolyPhen, CADD, and Ensembl Variant ... Then, we used MODELLER [26] homology modeling software to predict the ...
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50 SIFT.Hsapiens.dbSNP137 - TU Dortmund
https://bioconductor.statistik.tu-dortmund.de/packages/3.5/data/annotation/manuals/SIFT.Hsapiens.dbSNP137/man/SIFT.Hsapiens.dbSNP137.pdf
Details. The SIFT tool is no longer actively maintained. A few of the orginal authors have started the. PROVEAN (Protein Variation Effect Analyzer) project.
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51 Heuristic Methods for Finding Pathogenic Variants in Gene ...
https://www.ahajournals.org/doi/10.1161/JAHA.112.002642
SIFT, WT protein sequence (FASTA format) or Clustal‐formatted MSA (WT query sequence must appear first in MSA), variant/s of interest; MSA is ...
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52 Missense3D-DB web catalogue: an atom-based analysis and ...
https://link.springer.com/article/10.1007/s00439-020-02246-z
Population frequency and predictions from SIFT and PolyPhen are included ... with an appropriately parameterized software, three-dimensional ...
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53 SIFT: Predicting amino acid changes that affect protein function ...
https://www.wikidata.org/wiki/Q29547211
SIFT: Predicting amino acid changes that affect protein function. scientific article (publication date: July 2003). In more languages. Spanish.
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54 Residue mutations and their impact on protein structure and ...
https://portlandpress.com/biochemj/article/449/3/581/46112/Residue-mutations-and-their-impact-on-protein
Whereas point mutations can fine-tune the protein function, ... Tools such as SIFT Indel [154] or Polyscan can be used to detect indels, ...
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55 In silico tools used for the interpretation of novel variants ...
https://www.exeterlaboratory.com/genomics/in-silico-tools-used-for-the-interpretation-of-novel-variants/
SIFT (Sorting Intolerant From Tolerant) is an algorithm which predicts whether an amino acid substitution will affect protein function based on sequence ...
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56 Improving dbNSFP - DigitalCommons@TMC
https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1957&context=utgsbs_dissertations
prediction scores to indel annotation based on gene models, including CADD, SIFT, and. PROVEAN. All those scores can be calculated on-the-fly after ...
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57 SIFT.Hsapiens.dbSNP137
https://bioc.ism.ac.jp/packages/3.1/data/annotation/manuals/SIFT.Hsapiens.dbSNP137/man/SIFT.Hsapiens.dbSNP137.pdf
Details. The SIFT tool is no longer actively maintained. A few of the orginal authors have started the. PROVEAN (Protein Variation Effect ...
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58 Genome analysis of Yucatan miniature pigs to assess their ...
https://www.animbiosci.org/journal/view.php?number=24025
A SIFT score of <0.05 indicated that the SNP was deleterious and could strongly affect protein function. Moreover, we performed a PolyPhen-2 ( ...
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59 Identifying pathogenic amino acid substitutions in human ...
http://www.diva-portal.org/smash/get/diva2:1240447/FULLTEXT01.pdf
For example, a tool used for assessing if an amino acid substitution has an ef- fect on protein function, SIFT, does this by analyzing the conservation ...
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60 Meta-SNP - Meta-predictor of disease causing variants
https://snps.biofold.org/meta-snp/pages/methods.html
... acid substitutions and may affect protein function, often causing disease. ... scores of the variant predictions from PANTHER, PhD-SNP, SIFT and SNAP.
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61 Condel — FannsDB 2.0-dev documentation - BBGLab
https://bbglab.irbbarcelona.org/fannsdb/help/condel.html
Condel, SIFT, PolyPhen2, MutationAssessor, and FatHMM scores in FannsDB are now pre-computed for all possible variants in all human protein-coding genes.
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62 Schrödinger Suite : SLU
https://www.slu.edu/medicine/medical-education/graduate-programs/biochemistry-molecular-biology/facilities/gemini/software/schrodinger.php
Protein aggregation prediction · Identification of hot spots for proteolysis, glycosylation, deamidation, and oxidation · Residue-based analysis of energies, ...
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63 Variant Annotation Integrator - UCSC Genome Browser
https://genome.ucsc.edu/cgi-bin/hgVai
Protein-coding gene transcript effect predictions ; initiator_codon_variant, A codon variant that changes at least one base of the first codon of a transcript.
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64 snp-effect - SoftBerry
http://www.softberry.com/berry.phtml?topic=snp-effect&group=help&subgroup=snp
SNP-effect - Gene annotation and prediction of SIFT-like damaging effect · Whether a mutation is located in one of genes (including those predicted by the ...
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65 SIFT Workstation - SANS Institute
https://www.sans.org/tools/sift-workstation
The SIFT Workstation is a collection of free and open-source incident response and forensic tools designed to perform detailed digital forensic examinations ...
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66 Protein Chemistry - Online Analysis Tools
https://molbiol-tools.ca/Protein_Chemistry.htm
ProFound - is a tool for searching a protein sequence database using information from mass spectra of peptide maps. A Bayesian algorithm is used to rank the ...
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67 SIFT predictions for Homo sapiens dbSNP build 132
https://www.imsbio.co.jp/RGM/R_rdfile?f=SIFT.Hsapiens.dbSNP132/man/package.Rd&d=R_BC
Software : SIFT 4.0.3 ... Ng PC, Henikoff S. Predicting the Effects of Amino Acid Substitutions on Protein Function Annu Rev Genomics Hum Genet.
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68 UBE2N - Ubiquitin-conjugating enzyme E2 N | UniProtKB
https://www.uniprot.org/uniprotkb/P61088/entry
This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the ...
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69 Development of pathogenicity predictors specific for variants ...
http://pirepred.com/wp-content/uploads/2017/08/delaCampa2017.pdf
results are provided by software suites broadly used in the annotation of sequencing results in the clinical setting: SIFT, PolyPhen-2 ...
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70 Software | Protein Engineering Group - Loschmidt Laboratories
https://loschmidt.chemi.muni.cz/peg/software/
It combines six well-established computational methods (MAPP, PhD-SNP, PolyPhen-1, PolyPhen-2, SIFT, SNAP) with a two-level weighted consensus approach to ...
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71 Expasy: SIB Swiss Institute of Bioinformatics
https://www.expasy.org/
Other Resources of SIB Groups · Proteins & Proteomes. Software tool. Compute pI/MW · Genomics. Evolution & Phylogeny. Systems Biology · Glycomics. Software tool ...
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72 Aachange And Sift Tools - Galaxy Community Help
https://biostar.galaxyproject.org/p/2849/
Work with protein sequence in snpeff? Hi, I am knew to bioinformatics and I would like to know if it is possible to run the snpeff on ... False negative results ...
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73 NYSE: The New York Stock Exchange
https://www.nyse.com/index
... forgot to remind the arbiters of economic data that today was supposed to be quiet as there has been a ton of data to sift through.
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74 GTF3A mutations predispose to herpes simplex encephalitis ...
https://www.science.org/doi/10.1126/sciimmunol.abq4531
This showed that the GTF3A mRNA and TFIIIA protein expression ... (A) Genomic mapping of the ICR (top) using UROPA software (bottom panels).
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75 'Programmable molecular scissors' to snip COVID-causing virus
https://www.fiercebiotech.com/research/programmable-molecular-scissors-show-promise-against-viruses-starting-sars-cov-2
They expect you to provide all the enzymes and proteins they need to make ... of natural language processing software and other AI tools that sift through ...
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76 population collapse effects - NINE9
http://claro.nine9crmcenter.com.br/how-to/population-collapse-effects
eCollection 2022. Coding DNA sequence (CDS) alignments of each single-copy family were created based on the protein alignment, using MUSCLE65 software. Zheng, Q ...
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77 Sean Fraser: 'Unacceptable' that immigrant surgeons are ...
https://ca.finance.yahoo.com/news/sean-fraser-unacceptable-immigrant-surgeons-160607010.html
By way of example, Fraser said he can now sift through applications ... became too enamoured with recruiting coders and software engineers.
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78 Marginal REVOLUTION - Small Steps Toward A Much Better ...
https://marginalrevolution.com/
... that delivers the whole virus and not just the spike protein which is one reason ... A background in working with custom software and data pipelines for ...
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79 About EatingWell
https://www.eatingwell.com/about-eatingwell/
Finalist: Shaun Dreisbach, Protein Nation (April 2019) ... whether that's a registered dietitian who can sift through the science on the ...
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80 WoLF PSORT: Protein Subcellular Localization Prediction Tool
https://www.genscript.com/wolf-psort.html
WoLF PSORT is an extension of the PSORT II program for protein subcellular localization prediction, which is based on the PSORT principle.
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81 gnomAD
https://gnomad.broadinstitute.org/

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82 Have a protein you want inhibited? New software can design ...
https://arstechnica.com/science/2022/03/software-can-design-proteins-that-inhibit-proteins-on-viruses/
The software takes a protein's structure and designs proteins that stick to it. John Timmer - 3/25/2022, 10:42 AM. Image of a complex arrangement of colored ...
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83 Unravelling Complexities In Genetics And Genomics: Impact On ...
https://books.google.com/books?id=_W1tDQAAQBAJ&pg=PA124&lpg=PA124&dq=sift+software+protein&source=bl&ots=sNpb-YYzOe&sig=ACfU3U1zwUVPoUz-i-9nUrkwNC3pmqaD6w&hl=en&sa=X&ved=2ahUKEwic8qumlc_7AhX_m5UCHYFLAckQ6AF6BQjAAhAD
Various prediction software programs exist, including PolyPhen-2, SIFT, MutationTaster, ... the relation of protein to disease must also be considered.
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84 Animal Genetics and Diseases: Advances in Farming and ...
https://books.google.com/books?id=vnfQDwAAQBAJ&pg=PA106&lpg=PA106&dq=sift+software+protein&source=bl&ots=lhPe5aA6dj&sig=ACfU3U1U7nT5nTFsAbLedFqXpbzq-Nrspg&hl=en&sa=X&ved=2ahUKEwic8qumlc_7AhX_m5UCHYFLAckQ6AF6BQjEAhAD
The protein sequence of Tibetan goats was compared with the reference protein sequence of goats desmoglein-3. The cutoff value in the SIFT program is a ...
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85 Genetic Mutations Associated with Ocular Diseases
https://books.google.com/books?id=fMZcEAAAQBAJ&pg=PA98&lpg=PA98&dq=sift+software+protein&source=bl&ots=YNi17KFP4E&sig=ACfU3U3wNb0Q700i6w9tU5eTdlsPRF2Uzg&hl=en&sa=X&ved=2ahUKEwic8qumlc_7AhX_m5UCHYFLAckQ6AF6BQjDAhAD
Most of them encode proteins necessary for the formation of the BBSome ... and four software prediction programs: Sorting Intolerant from Tolerance (SIFT), ...
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86 Practical Genetic Counseling for the Laboratory
https://books.google.com/books?id=3up0DgAAQBAJ&pg=PA136&lpg=PA136&dq=sift+software+protein&source=bl&ots=S-VQxPk0lj&sig=ACfU3U0WRMB045q25mDdPqxUht6uyhmLZA&hl=en&sa=X&ved=2ahUKEwic8qumlc_7AhX_m5UCHYFLAckQ6AF6BQjBAhAD
... effect on protein formation (i.e., truncating variants such as nonsense, ... by in silico analysis software programs such as POLYPHEN and SIFT), ...
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87 Bioinformatics - Google Books Result
https://books.google.com/books?id=ZF_SDwAAQBAJ&pg=PT812&lpg=PT812&dq=sift+software+protein&source=bl&ots=kA-Q0qbCpI&sig=ACfU3U283AfOuds7epdVQeS8waHRUnK9mA&hl=en&sa=X&ved=2ahUKEwic8qumlc_7AhX_m5UCHYFLAckQ6AF6BQi_AhAD
Pathogenic variants tend to occur non-randomly in protein structures and tend to be ... Examples of these methods include SIFT (Ng and Henikoff 2003), ...
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